Table 2 The phenotypes, stimulators and effects of intratumoral γδT cells
From: In respond to commensal bacteria: γδT cells play a pleiotropic role in tumor immunity
Phenotype | Stimulator | Effect | References |
|---|---|---|---|
γδT17 | IL-7; IL-1, IL-23; TGF-β, IL-6 | Recruit PMN-MDSC and TAN, increase VEGF, express anti-apoptotic genes | |
γδTreg | TGF-β, IL-15 | Increase adenosine, inhibit γδTh1 | |
γδTh1 | IL-2, IL-15 | Secret IFN-γ | |
γδT-APC | PAMP | Regulate CD4+ or CD8+ T cells, induce mucosa to release calprotectin |