Table 2 The phenotypes, stimulators and effects of intratumoral γδT cells
From: In respond to commensal bacteria: γδT cells play a pleiotropic role in tumor immunity
| Phenotype | Stimulator | Effect | References |
|---|---|---|---|
| γδT17 | IL-7; IL-1, IL-23; TGF-β, IL-6 | Recruit PMN-MDSC and TAN, increase VEGF, express anti-apoptotic genes | [43, 44, 47, 70, 75] |
| γδTreg | TGF-β, IL-15 | Increase adenosine, inhibit γδTh1 | [49, 80] |
| γδTh1 | IL-2, IL-15 | Secret IFN-γ | [51, 52] |
| γδT-APC | PAMP | Regulate CD4+ or CD8+ T cells, induce mucosa to release calprotectin | [67, 68] |