Fig. 3

ApoE4 (Δ272–299) induces the imbalance of mitochondrial fusion and fission in vivo and in vitro. a, b Western blot analysis of the relative levels of MFF, MFN2, MFN1 and OPA1 expression and DRP1 phosphorylation in the hippocampus of apoE4 (Δ272–299) transgenic and wild-type mice. c, d Western blot analysis of the relative levels of MFF, MFN2, MFN1 and OPA1 expression and DRP1 phosphorylation in the apoE4 (Δ272–299) expressed N2a and control cells. Data are representative images or expressed as the mean ± SEM of each group (n = 3) from three separate experiments. **P < 0.01 versus the wild-type mice; ^##P < 0.01, ^#P < 0.05 versus the control N2a cells transfected with the pIRES vector. The significant differences were determined by ANOVA and post hoc Fisher’s least significant difference