Fig. 5

RNA-sequencing analysis of LncRNA-Dnm3os regulated genes in chondrogenesis. a Quantitative RNA-seq comparison of differentially expressed genes in FL and DKO transfected primary articular chondrocytes. Total number of genes with at least 1.15-log2Fold Change are indicated. b Heat map representation of the top 8 enriched pathway with highest fold change in FL and DKO transfected primary articular chondrocytes. c Top 20 enriched Reactome pathways in FL and DKO transfected primary articular chondrocytes. The size and color of the dots represent the enriched gene number and the range of p values, respectively. d Genes associated with chondrogenesis that are up- or down-regulated in FL and DKO transfected primary articular chondrocytes. e Verification of LncRNA-Dnm3os regulated genes in (d) by RT-qPCR in chondrocytes transfected by RK5, FL, DKO and miR214 individually. Student T-test was used for statistical analysis. *P < 0.1 and **P < 0.01