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Table 4 Univariate and multivariate analyses of the recurrence-free survival in 135 HCC cases

From: DNA primase subunit 1 deteriorated progression of hepatocellular carcinoma by activating AKT/mTOR signaling and UBE2C-mediated P53 ubiquitination

Parameters Univariate analysis Multivariate analysis
HR 95% CI P HR 95% CI P
PRIM1 expression
High vs. low 3.283 2.083–5.173 < 0.001 1.733 1.038–2.893 0.036
Age (years)
 < 60 vs. ≥ 60 0.857 0.520–1.414 0.545    
Sex
 Male vs. female 1.026 0.579–1.819 0.930    
AFP level
 Positive vs. negative 1.520 0.894–2.586 0.119    
Tumor size (cm)
 < 3 vs. ≥ 3 3.311 1.654–6.627 < 0.001 1.849 0.873–3.915 0.108
Edmondson-Steiner grade
 I + II vs. III + IV 2.172 1.048–4.503 0.032 1.878 0.882–3.997 0.102
Ascites
 Absent vs. present 2.405 1.541–3.754 < 0.001 2.431 1.516–3.898 < 0.001
 TNM stage
I + II vs. III + IV 3.024 1.903–4.805 < 0.001 2.201 1.306–3.707 0.003
  1. PRIM1 DNA primase subunit 1, TNM tumor-node-metastasis