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Table 2 Effect of DNA methylation on miRNAs

From: Overview of host miRNA properties and their association with epigenetics, long non-coding RNAs, and Xeno-infectious factors

miRNA Expression Mechanism Disease Refs.
miR-874 Down expressed Hyper methylation of the promoter region Breast cancer [194]
miR-129-2 and miR-9-1 Down expressed DNA methylation of the miRNA promoter CpG island Renal cell carcinoma [75]
miR- 10b-3p Over expressed Promoter hypo methylation Esophageal squamous cell carcinoma [195]
miR-141 Down expressed Hyper DNA methylation Gastric cancer [108]
miR -145 Over expressed Demethylation of the promoter region Breast cancer [50]
miR-200c and miR-141 Over expressed Hypomethylation of the promoter region Colorectal Cancer [109]
miR-200c/141 Down expressed Hyper methylation of CpG island located in the promoter region Invasive breast cancer [114]
miR-370 Down expressed Hyper methylation of two CpG islands located in the upstream of miR genomic locus Osteosarcoma [196]
miR-941 and miR-1247 Down expressed Hyper methylation of the CpG island in miRs loci Gastric cancer [197]
miR‐7‐5p Down expressed Hyper methylation of the promoter site Gastric cancer [116]
miR-21 and miR-146b Over expressed Hypo methylation of miRs promoter region Papillary thyroid carcinoma [198]
miR124-2 Over expressed Hypo methylation of CpG site in miR gene Breast Cancer [199]
miR-183 Down expressed Hyper methylation of the miR promoter Hepatocellular carcinoma [200]