Table 2 Effect of DNA methylation on miRNAs
miRNA | Expression | Mechanism | Disease | Refs. |
|---|---|---|---|---|
miR-874 | Down expressed | Hyper methylation of the promoter region | Breast cancer | [194] |
miR-129-2 and miR-9-1 | Down expressed | DNA methylation of the miRNA promoter CpG island | Renal cell carcinoma | [75] |
miR- 10b-3p | Over expressed | Promoter hypo methylation | Esophageal squamous cell carcinoma | [195] |
miR-141 | Down expressed | Hyper DNA methylation | Gastric cancer | [108] |
miR -145 | Over expressed | Demethylation of the promoter region | Breast cancer | [50] |
miR-200c and miR-141 | Over expressed | Hypomethylation of the promoter region | Colorectal Cancer | [109] |
miR-200c/141 | Down expressed | Hyper methylation of CpG island located in the promoter region | Invasive breast cancer | [114] |
miR-370 | Down expressed | Hyper methylation of two CpG islands located in the upstream of miR genomic locus | Osteosarcoma | [196] |
miR-941 and miR-1247 | Down expressed | Hyper methylation of the CpG island in miRs loci | Gastric cancer | [197] |
miR‐7‐5p | Down expressed | Hyper methylation of the promoter site | Gastric cancer | [116] |
miR-21 and miR-146b | Over expressed | Hypo methylation of miRs promoter region | Papillary thyroid carcinoma | [198] |
miR124-2 | Over expressed | Hypo methylation of CpG site in miR gene | Breast Cancer | [199] |
miR-183 | Down expressed | Hyper methylation of the miR promoter | Hepatocellular carcinoma | [200] |