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Table 3 Integrative metabolic pathways analysis on results obtained from combined metabolomics and gene expression

From: Transcriptomic and metabolomic profiling reveal the p53-dependent benzeneacetic acid attenuation of silica‐induced epithelial–mesenchymal transition in human bronchial epithelial cells

Pathway name Match status p Impact
Glyoxylate and dicarboxylate metabolism 10/92 0.000174 0.25455
Citrate cycle (TCA cycle) 8/142 0.000391 0.65854
Arginine biosynthesis 6/76 0.000679 0.30769
Butanoate metabolism 6/77 0.000899 0.32143
Alanine, aspartate and glutamate metabolism 6/82 0.002202 0.18333
Phenylalanine metabolism 5/50 0.003821 0.55
Biosynthesis of unsaturated fatty acids 6/106 0.005523 0.086957
Linoleic acid metabolism 5/64 0.027727 0.875
Propanoate metabolism 6/115 0.037239 0.19149
Glutathione metabolism 5/70 0.054837 0.18182
Glycine, serine and threonine metabolism 4/44 0.08738 0.38806
Fatty acid biosynthesis 4/70 0.13803 0.039062
d-Glutamine and d-glutamate metabolism 5/132 0.14551 0.22222
Synthesis and degradation of ketone bodies 4/79 0.14551 0.55556
Pyruvate metabolism 4/92 0.15422 0.18182
Tyrosine metabolism 4/114 0.15534 0.057471
Phenylalanine, tyrosine and tryptophan biosynthesis 3/57 0.15888 0.5
Alpha-Linolenic acid metabolism 4/117 0.29307 0.095238
Mucin type O-glycan biosynthesis 3/74 0.29307 0.14286
Arachidonic acid metabolism 4/148 0.36168 0.325
Tryptophan metabolism 3/90 0.37875 0.024096
Valine, leucine and isoleucine degradation 2/33 0.40123 0.08046
Glycerolipid metabolism 3/94 0.42493 0.088235
Terpenoid backbone biosynthesis 3/94 0.43402 0.057143
Ether lipid metabolism 3/98 0.46045 0.10526
Fatty acid degradation 2/43 0.47685 0.029703
Nicotinate and nicotinamide metabolism 3/124 0.48567 0.097561
Beta-Alanine metabolism 2/69 0.50185 0.046512
Pentose phosphate pathway 2/73 0.52518 0.021739
Lysine degradation 1/12 0.54015 0.0625
Porphyrin and chlorophyll metabolism 2/79 0.56871 0.019231
Sphingolipid metabolism 2/89 0.60199 0.035088
Glycolysis or Gluconeogenesis 2/90 0.62074 0.083333
Aminoacyl-tRNA biosynthesis 3/194 0.69254 0.013699
Fatty acid elongation 2/98 0.69748 0.027027