Table 3 Integrative metabolic pathways analysis on results obtained from combined metabolomics and gene expression

Glyoxylate and dicarboxylate metabolism

10/92

Citrate cycle (TCA cycle)

8/142

Arginine biosynthesis

6/76

Butanoate metabolism

6/77

Alanine, aspartate and glutamate metabolism

6/82

Phenylalanine metabolism

5/50

Biosynthesis of unsaturated fatty acids

6/106

Linoleic acid metabolism

5/64

Propanoate metabolism

6/115

Glutathione metabolism

5/70

Glycine, serine and threonine metabolism

4/44

Fatty acid biosynthesis

4/70

d-Glutamine and d-glutamate metabolism

5/132

Synthesis and degradation of ketone bodies

4/79

Pyruvate metabolism

4/92

Tyrosine metabolism

4/114

Phenylalanine, tyrosine and tryptophan biosynthesis

3/57

Alpha-Linolenic acid metabolism

4/117

Mucin type O-glycan biosynthesis

3/74

Arachidonic acid metabolism

4/148

Tryptophan metabolism

3/90

Valine, leucine and isoleucine degradation

2/33

Glycerolipid metabolism

3/94

Terpenoid backbone biosynthesis

3/94

Ether lipid metabolism

3/98

Fatty acid degradation

2/43

Nicotinate and nicotinamide metabolism

3/124

Beta-Alanine metabolism

2/69

Pentose phosphate pathway

2/73

Lysine degradation

1/12

Porphyrin and chlorophyll metabolism

2/79

Sphingolipid metabolism

2/89

Glycolysis or Gluconeogenesis

2/90

Aminoacyl-tRNA biosynthesis

3/194

Fatty acid elongation

2/98