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Table 1 Top 20 differential expressed genes/mRNAs in the p53-wt vs. p53-KO HBE cells post 12.5 µg/mL silica

From: Transcriptomic and metabolomic profiling reveal the p53-dependent benzeneacetic acid attenuation of silica‐induced epithelial–mesenchymal transition in human bronchial epithelial cells

Upregulated mRNA Downregulated mRNA
Gene-ID Fold change Log2 (Fold) p value Gene-ID Fold change Log2 (Fold) p value
ANKRD22 11.33825 3.503126 0.031888 SLC9B1 0.062922  − 3.99028 0.023555
GALNT16 5.9697 2.577658 0.015915 GOLGA8Q 0.067677  − 3.88519 0.040364
LGR5 5.805771 2.537488 0.00641 FAM19A5 0.068239  − 3.87326 0.033308
ITGA9 5.201689 2.37898 0.033195 LAIR2 0.07763  − 3.68725 0.035158
ELMOD1 5.045316 2.334945 0.038847 PLA2G2C 0.182084  − 2.45733 0.024876
GPT 4.512969 2.174077 0.042918 TNFRSF10C 0.215358  − 2.21519 0.018619
SCG3 4.258003 2.090177 0.028393 NEU4 0.227828  − 2.13399 0.040534
DEFA5 3.533064 1.82092 5.51E-05 VAV1 0.325185  − 1.62067 0.002011
DEFA6 3.417341 1.772874 0.002371 SHC2 0.36299  − 1.462 0.044092
CRYBB2 3.367854 1.751829 0.022507 LOC107985524 0.384776  − 1.37791 0.040135
JAKMIP2 3.267922 1.708373 0.022156 DLX2 0.394143  − 1.34321 0.022467
ZNF385B 3.169598 1.6643 0.018243 FNTB 0.437081  − 1.19403 0.039543
PRSS2 2.980291 1.575453 0.046668 COL8A2 0.456718  − 1.13063 0.006895
RNF103-CHMP3 2.964665 1.567869 0.00646 PSG8 0.458618  − 1.12464 0.015305
CHRNA1 2.764834 1.467193 0.009205 SLC35F3 0.465274  − 1.10385 0.041656
LRRC46 2.747 1.457857 0.04034 AS3MT 0.466297  − 1.10068 0.006206
ADCY4 2.725217 1.446371 0.008368 TREM2 0.47154  − 1.08455 0.000655
LIX1 2.71129 1.438979 0.041953 KCNMA1 0.479557  − 1.06023 0.002141
KCND3 2.666753 1.415084 0.015511 NANOS3 0.486488  − 1.03952 0.046132
SLC24A3 2.665332 1.414315 0.033314 SLC45A1 0.491734  − 1.35907 0.008291
  1. p < 0.05 represents significantly changed