Fig. 3

Top six upregulated or downregulated metabolites in the p53-KO group compared with that of the p53-wt group post silica exposure. a Top six upregulated metabolites in the p53-KO group compared with that of the p53-wt group post silica exposure. b Top six downregulated metabolites in the p53-KO group compared with that of the p53-wt group post silica exposure. VIP means variable importance in the projection