Integrin αIIbβ3 outside-in signaling activates human platelets through serine 24 phosphorylation of Disabled-2

Cell & Bioscience

Table 1 Dab2-Ser24 and its flanking sequences are conserved among different species

Species	AA#	P-Site	Sequence	GenBank accession number
Human	770	S24	¹⁸AAPKAPSKKEKKK³⁰	NP_001334.2
Chimpanzee	770	S24	¹⁸AAPKAPSKKEKKK³⁰	JAA20332.1
Rhesus Macaque	770	S24	¹⁸AAPKAPSKKEKKK³⁰	AFI34301.1
Dog	770	S24	¹⁸AAPKAPSKKEKKK³⁰	XP_536493.2
Platypus	758	S24	¹⁸TAPKVPSKKEKKK³⁰	XP_001507342.2
Rat	768	S24	¹⁸AAPKAPSKKEKKK³⁰	NP_077073.1
Mouse	766	S24	¹⁸AAPKAPSKKEKKK³⁰	NP_075607.2
Hamster	765	S24	¹⁸AAPKVPSKKEKKK³⁰	XP_003503146.1
Chicken	715	S26	²⁰PPKAQTSKKEKKK³²	XP_015133025.1
Frog	555	S24	¹⁸PTAKPPSKKEKKK³⁰	NP_001165652.1
Zebra Danio	668	S21	¹⁵PPFKTPSKKEKKK²⁷	XP_001920879.3

AA# number of amino acids, P-Site the amino acid corresponding to human Dab2 Ser24 phosphorylation site

ISSN: 2045-3701