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TableĀ 1 Factors modulating H3K36me3 and their susceptibility to cancers

From: DNA mismatch repair in the context of chromatin

Function Enzyme Related cancers
Methyltransferase ASH1L Sinonasal neuroendocrine tumors, lung cancer, prostate cancer
NSD1 Acute myeloid leukemia, prostate, neuroblastoma, breast, lung, glioma
NSD2 Multiple myeloma, acute lymphocytic leukemia, prostate
NSD3 Acute myeloid leukemia, breast cancer
PRDM9 Acute lymphocytic leukemia
SETD2 Renal clear cell carcinoma, lymphoblastic leukemia, breast cancer, prostate cancer, lung cancer, glioma, thymic carcinoma, acute myeloid leukemia
SETD3 Renal cell carcinoma, B-cell lymphomas
SETMAR Acute myeloid leukemia, breast cancer
SMYD2 Renal cell, acute myeloid leukemia, chronic lymphocytic leukemia, breast cancer
Demethylase KDM2A Gastric, breast, lung
KDM2B Pancreatic, hematologic
KDM4A Breast, prostate
KDM4B Breast, prostate, colon, gastric, lung, melanoma
KDM4C Breast, lung, prostate, melanoma, lymphoma
NO66 Renal cell, colorectal
Histone mutation H3K36M/I Glioblastoma, head and neck squamous cell carcinoma, chondroblastomas, sarcoma
H3G34V/R/D Glioblastoma, glioma, chondroblastomas, sarcoma, colon
Other factors ASF1 NA
CTK1 NA
IDH1 Acute myeloid leukemia, glioma
SPT6 Skin, bladder, colorectal