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TableĀ 1 Factors modulating H3K36me3 and their susceptibility to cancers

From: DNA mismatch repair in the context of chromatin

FunctionEnzymeRelated cancers
MethyltransferaseASH1LSinonasal neuroendocrine tumors, lung cancer, prostate cancer
NSD1Acute myeloid leukemia, prostate, neuroblastoma, breast, lung, glioma
NSD2Multiple myeloma, acute lymphocytic leukemia, prostate
NSD3Acute myeloid leukemia, breast cancer
PRDM9Acute lymphocytic leukemia
SETD2Renal clear cell carcinoma, lymphoblastic leukemia, breast cancer, prostate cancer, lung cancer, glioma, thymic carcinoma, acute myeloid leukemia
SETD3Renal cell carcinoma, B-cell lymphomas
SETMARAcute myeloid leukemia, breast cancer
SMYD2Renal cell, acute myeloid leukemia, chronic lymphocytic leukemia, breast cancer
DemethylaseKDM2AGastric, breast, lung
KDM2BPancreatic, hematologic
KDM4ABreast, prostate
KDM4BBreast, prostate, colon, gastric, lung, melanoma
KDM4CBreast, lung, prostate, melanoma, lymphoma
NO66Renal cell, colorectal
Histone mutationH3K36M/IGlioblastoma, head and neck squamous cell carcinoma, chondroblastomas, sarcoma
H3G34V/R/DGlioblastoma, glioma, chondroblastomas, sarcoma, colon
Other factorsASF1NA
IDH1Acute myeloid leukemia, glioma
SPT6Skin, bladder, colorectal