Table 1 Factors modulating H3K36me3 and their susceptibility to cancers
Function | Enzyme | Related cancers |
|---|---|---|
Methyltransferase | ASH1L | Sinonasal neuroendocrine tumors, lung cancer, prostate cancer |
NSD1 | Acute myeloid leukemia, prostate, neuroblastoma, breast, lung, glioma | |
NSD2 | Multiple myeloma, acute lymphocytic leukemia, prostate | |
NSD3 | Acute myeloid leukemia, breast cancer | |
PRDM9 | Acute lymphocytic leukemia | |
SETD2 | Renal clear cell carcinoma, lymphoblastic leukemia, breast cancer, prostate cancer, lung cancer, glioma, thymic carcinoma, acute myeloid leukemia | |
SETD3 | Renal cell carcinoma, B-cell lymphomas | |
SETMAR | Acute myeloid leukemia, breast cancer | |
SMYD2 | Renal cell, acute myeloid leukemia, chronic lymphocytic leukemia, breast cancer | |
Demethylase | KDM2A | Gastric, breast, lung |
KDM2B | Pancreatic, hematologic | |
KDM4A | Breast, prostate | |
KDM4B | Breast, prostate, colon, gastric, lung, melanoma | |
KDM4C | Breast, lung, prostate, melanoma, lymphoma | |
NO66 | Renal cell, colorectal | |
Histone mutation | H3K36M/I | Glioblastoma, head and neck squamous cell carcinoma, chondroblastomas, sarcoma |
H3G34V/R/D | Glioblastoma, glioma, chondroblastomas, sarcoma, colon | |
Other factors | ASF1 | NA |
CTK1 | NA | |
IDH1 | Acute myeloid leukemia, glioma | |
SPT6 | Skin, bladder, colorectal |