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Fig. 5 | Cell & Bioscience

Fig. 5

From: Loss of PI3 kinase association improves the sensitivity of secondary mutation of KIT to Imatinib

Fig. 5

Loss of PI3 kinase association improves the sensitivity of secondary mutations of KIT to Imatinib in vivo. 6 × 106 Ba/F3 cells stably expressing KIT mutant in PBS containing 10% Matrixgel were subcutaneously injected into right flank of nude mice. a The days of tumor formation were calculated. When the tumor size reaches 100 mm3 (W557K558del/V654A) or 300 mm3 (W557K558del/V654A/M724A), mice were treated with KIT inhibitor Imatinib (50 mg/kg) daily and/or PI3 kinase inhibitor Copanlisib (6 mg/kg) every other day for 10 days. After sacrifice, b, c the tumor size and weight were measured and tumor volume was calculated N = 4)

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