Fig. 1

Schematic diagram showing the proteins involved in dePARylation. The acceptor protein is shown as beads on a string. The dominant amino acids involved in PARylation (i.e. aspartic acid and glutamic acid are shown light blue, arginine is shown in dark blue, serine is shown in light green). A dsDNA helix is and MAR moiety attached to it is shown in black. The bonds hydrolyzed by different dePARylation proteins are shown. A linear and branched PAR chain is shown attached to aspartic acid and glutamic acid