Skip to main content

Table 5 Echocardiographic results of mice after inhibition of HDAC3 and miR-18a and overexpression of ADRB3

From: The crosstalk of HDAC3, microRNA-18a and ADRB3 in the progression of heart failure

Group\parameter

LVPWD (mm)

IVSD (mm)

LVEDD (mm)

LVESD (mm)

LVEF (%)

LVFS (%)

HF + sh-NC

1.31 ± 0.16

0.81 ± 0.09

4.42 ± 0.54

3.91 ± 0.45

15.47 ± 1.78

11.31 ± 1.33

HF + sh-HDAC3

1.88 ± 0.19 *

0.54 ± 0.07 *

3.79 ± 0.41 *

2.57 ± 0.23 *

31.97 ± 4.49 *

32.13 ± 1.84 *

HF + sh-HDAC3 + NC-antagomir

1.96 ± 0.22

0.63 ± 0.07

4.01 ± 0.32

2.74 ± 0.20

31.44 ± 3.83

30.68 ± 2.68

HF + sh-HDAC3 + miR-18a-antagomir

1.63 ± 0.14 #

0.96 ± 0.11 #

4.88 ± 0.43 #

3.68 ± 0.34 #

24.68 ± 2.43 #

24.39 ± 2.17 #

HF + sh-HDAC3 + oe-NC

1.82 ± 0.21

0.61 ± 0.07

3.87 ± 0.32

2.60 ± 0.21

32.80 ± 3.42

29.97 ± 2.19

HF + sh-HDAC3 + oe-ADRB3

1.56 ± 0.17 &

0.92 ± 0.09 &

4.53 ± 0.43 &

3.90 ± 0.34 &

13.96 ± 1.26 &

14.57 ± 1.14 &

  1. * p < 0.05 vs. HF mice treated with sh-NC. # p < 0.05 vs. HF mice treated with sh-HDAC3 + NC-antagomir. & p < 0.05 vs. HF mice treated with sh-HDAC3 + oe-NC. One-way ANOVA was utilized for comparisons among multiple groups, and Tukey’s post-hoc test was employed for intra-group pairwise comparison
Back to article page

Cell & Bioscience

ISSN: 2045-3701

Contact us