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Table 1 Echocardiographic results of mice after miR-18a inhibition

From: The crosstalk of HDAC3, microRNA-18a and ADRB3 in the progression of heart failure

Group\parameter

LVPWD (mm)

IVSD (mm)

LVEDD (mm)

LVESD (mm)

LVEF (%)

LVFS (%)

Sham

1.48 ± 0.18

0.51 ± 0.05

3.74 ± 0.49

1.77 ± 0.19

51.87 ± 8.98

52.67 ± 6.23

HF

1.11 ± 0.13*

0.69 ± 0.07*

4.71 ± 0.61*

3.73 ± 0.29*

17.55 ± 1.85*

11.82 ± 1.54*

HF + NC-agomir

1.02 ± 0.09

0.72 ± 0.11

4.52 ± 0.45

3.91 ± 0.41

16.22 ± 1.66

10.32 ± 1.28

HF + miR-18a-agomir

1.54 ± 0.08#

0.59 ± 0.07#

3.89 ± 0.16#

1.91 ± 0.28#

50.79 ± 7.53#

49.47 ± 4.94#

  1. * p < 0.05 vs. sham-operated mice; # p < 0.05 vs. the HF mice injected with NC-agomir. One-way ANOVA was utilized for comparisons among multiple groups, and Tukey’s post-hoc test was employed for intra-group pairwise comparison
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Cell & Bioscience

ISSN: 2045-3701

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