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Table 1 Echocardiographic results of mice after miR-18a inhibition

From: The crosstalk of HDAC3, microRNA-18a and ADRB3 in the progression of heart failure

Group\parameter LVPWD (mm) IVSD (mm) LVEDD (mm) LVESD (mm) LVEF (%) LVFS (%)
Sham 1.48 ± 0.18 0.51 ± 0.05 3.74 ± 0.49 1.77 ± 0.19 51.87 ± 8.98 52.67 ± 6.23
HF 1.11 ± 0.13* 0.69 ± 0.07* 4.71 ± 0.61* 3.73 ± 0.29* 17.55 ± 1.85* 11.82 ± 1.54*
HF + NC-agomir 1.02 ± 0.09 0.72 ± 0.11 4.52 ± 0.45 3.91 ± 0.41 16.22 ± 1.66 10.32 ± 1.28
HF + miR-18a-agomir 1.54 ± 0.08# 0.59 ± 0.07# 3.89 ± 0.16# 1.91 ± 0.28# 50.79 ± 7.53# 49.47 ± 4.94#
  1. * p < 0.05 vs. sham-operated mice; # p < 0.05 vs. the HF mice injected with NC-agomir. One-way ANOVA was utilized for comparisons among multiple groups, and Tukey’s post-hoc test was employed for intra-group pairwise comparison