Fig. 1

Macrophage-specific Fpn1 deficiency promotes atherosclerosis progression. Apoe^−/− and Apoe^−/−Fpn1^LysM/LysM male mice were fed a high fat diet for 16 weeks. a Representative images of Oil Red O staining of en face preparations of aortas.b Quantification of the aortic lesion area, n = 20. c, d Determination of aortic root lesion area and size, n = 4. e Representative images of Oil Red O staining and fquantification of lipid content in the aortic root in Apoe^−/− and Apoe^−/−Fpn1^LysM/LysM mice, n = 4. Scale bar, 100 μm. Data are presented as the mean ± SEM. Statistical significance was determined using Student’s t-test. **P < 0.01, and ***P < 0.001 vs. Apoe^−/− mice