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Table 1 Clinicopathologic parameters according to adjuvant radiotherapy classification in Stage I patients of TCGA UCEC cohort

From: Integrating pathology, chromosomal instability and mutations for risk stratification in early-stage endometrioid endometrial carcinoma

Prognostic factors Total OB VBT EBRT P  
n = 294 (100%) n= 123 (42%) n = 92 (31%) n= 79 (27%)
Agea
 Mean (range) 64 (31–90) 60 (31–89) 66 (35–90) 68 (35–87) 0.000 ANOVAb
 < 60 97 (33%) 65 (53%) 20 (22%) 12 (15%) 0.000 Pearson Chi2
 ≥ 60 195 (67%) 58 (47%) 71 (78%) 66 (85%)   
Histologic type      0.000 Pearson Chi2
 Type I, EEC 250 (85%) 123 (100%) 92 (100%) 35 (44%)   
 Type II, non-EEC 44 (15%) 0 0 44 (56%)   
Grade      0.000 Pearson Chi2
 1 76 (26%) 66 (54%) 10 (11%) 0   
 2 76 (26%) 57 (46%) 20 (22%) 1(1%)   
 3 140 (48%) 0 62 (67%) 78 (99%)   
Stagec      0.000 Pearson Chi2
 IA, MI < 50% 199 (68%) 105 (87%) 62 (67%) 32 (41%)   
 IB, MI > 50% 92 (32%) 16 (13%) 30 (33%) 46 (59%)   
CIN expression
 CIN25 Mean (range) −0.03 (−1.45–3.24) −0.41 (−1.45–2.38) 0.18 (−1.20–3.24) 0.54 (−1.29–2.23) 0.000 ANOVA
 CIN70 Mean (range) −0.03 (−1.53–3.07) −0.38 (−1.53–1.95) 0.17 (−1.09–3.07) 0.50 (−1.14–1.86) 0.000 ANOVA
Aneuploidy score 4.82 (0–31) 2.35 (0–20) 4.38 (0–27) 9.18 (0–31) 0.000 ANOVA
FGA 0.15 (0–0.95) 0.08 (0– 0.95) 0.15 (0–0.81) 0.25 (0–0.69) 0.000 ANOVA
Guidelines risk groupd      0.000 Pearson Chi2
 Low 105 (36%) 105 (87%) 0 0   
 Intermediate 46 (16%) 16 (13%) 30 (33%) 0   
 High-intermediate 62 (21%) 0 62 (67%) 0   
 High 79 (27%) 0 0 79 (100%)   
TCGA subtype      0.000 Pearson Chi2
 POLE-mutant 29 (10%) 12 (10%) 10 (11%) 7 (9%)   
 MSI 99 (34%) 39 (32%) 37 (40%) 23 (29%)   
 CNV Low 101 (34%) 67 (54%) 25 (27%) 9 (11%)   
 CNV High 65 (22%) 5 (4%) 20 (22%) 40 (51%)   
Mutation
  PTEN 223 (76%) 111 (90%) 73 (79%) 39 (49%) 0.000 Pearson Chi2
  FGFR2 59 (20%) 23 (19%) 22 (24%) 14 (18%) n.s. Pearson Chi2
  CTNNB1 72 (24%) 44 (36%) 22 (24%) 6 (8%) 0.000 Pearson Chi2
 PIK3CA 147 (50%) 67 (54%) 47 (51%) 33 (42%) n.s. Pearson Chi2
 PPP2R1A 40 (14%) 5 (4%) 12 (13%) 23 (29%) 0.000 Pearson Chi2
  1. aFor the two cases without age, one was in VBT group, another was in EBRT group
  2. bOne-way analysis of variance
  3. cFor the three cases without accurate MI, two were in OB group, one was in EBRT group
  4. dThere were two cases in OB group without complete clinicopathological information for guidelines risk assessment