Fig. 1
From: Advances in the role of m6A RNA modification in cancer metabolic reprogramming
The process and molecular functions of m6A methylation. The effectors in m6A include ‘writers’, ‘readers’ and ‘erasers’. Writer methyltransferase installs m6A methylation on target RNAs via the methyl groups of S-adenosylmethionine (SAM) transferase. FTO and ALKBH5 were two major RNA demethylases that catalyze the removal of m6A on RNA in a Fe(II)/α-KG (α-ketoglutarate)-dependent manner. Methyltransferases and demethylases cooperate in modulating the distribution and abundance of m6A in RNAs, meanwhile the ‘readers’ specifically recognize and bind m6A-RNAs to control their fate and regulate downstream functions