Fig. 1

NRP2 expression is positively correlated with PNET vascularity. a Heatmap summarizing the angiogenesis process signature (GSE73514) in metastatic-like primary (MLP) tumor and islet tumor (IT) samples. b Top: Comparison of NRP2 mRNA expression between the MLP and IT groups. Bottom: GSEA mountain plot showing a strong association between the MLP and IT groups. The data are presented as the means ± SD. *P ≤ 0.05 by Student’s t test. C, Representative expression of CD31, VEGFR2 and NRP2 in non-small-cell lung cancer (NSCLC), colorectal cancer (CRC) and pancreatic neuroendocrine tumor (PNET) specimens according to immunohistochemistry assays. d Correlation histograms of CD31, VEGFR2 and NRP2 expression in NSCLC, CRC and PNET specimens according to immunohistochemistry. Each number on the horizontal axis represents one specimen from the patients. The bars in the histograms show the mean percentage of positively staining cells under 5 randomly selected microscopic fields (20x). The Spearman R value and P value in the figures reflect the correlations of NRP2 and CD31 expression