Epigenetic regulation of matrix metalloproteinases in inflammatory diseases: a narrative review

Cell & Bioscience

Table 2 Role of HDAC inhibitors and HAT inhibitors in MMPs

	Target genes	Inflammatory diseases	References
HDAC inhibitors
MS-275	MMP-1↓	Pulmonary tuberculosis	[17]
MS-275	MMP-9↓	Experimental autoimmune neuritis.	[38]
CBHA	MMP-1↓	Pulmonary tuberculosis	[17]
TSA	MMP-1/-3↓	Pulmonary tuberculosis	[17]
TSA and NaBy	MMP-1 and MMP-13↓	Arthritis	[42]
HAT inhibitors
AA	MMP-1/-3↓	Pulmonary tuberculosis	[17]
HATi II	MMP-1/-3↓	Pulmonary tuberculosis	[17]

HDAC, histone deacetylases; HAT, histone acetylation; CBHA, m-Carboxycinnamic Acid bis-Hydroxamide; TSA, Trichostatin A; NaBy, sodium butyrate; AA, Anacardic acid; MMP, matrix metalloproteinase

ISSN: 2045-3701