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Table 2 Role of HDAC inhibitors and HAT inhibitors in MMPs

From: Epigenetic regulation of matrix metalloproteinases in inflammatory diseases: a narrative review

  Target genes Inflammatory diseases References
HDAC inhibitors
 MS-275 MMP-1↓ Pulmonary tuberculosis [17]
MMP-9↓ Experimental autoimmune neuritis. [38]
 CBHA MMP-1↓ Pulmonary tuberculosis [17]
 TSA MMP-1/-3↓ [17]
 TSA and NaBy MMP-1 and MMP-13↓ Arthritis [42]
HAT inhibitors
 AA MMP-1/-3↓ Pulmonary tuberculosis [17]
 HATi II
  1. HDAC, histone deacetylases; HAT, histone acetylation; CBHA, m-Carboxycinnamic Acid bis-Hydroxamide; TSA, Trichostatin A; NaBy, sodium butyrate; AA, Anacardic acid; MMP, matrix metalloproteinase