Fig. 3
From: The functions and mechanisms of prefoldin complex and prefoldin-subunits
Multiple roles and physical interactions with proteins of prefoldin subunits. Prefoldin subunits can play an important role in different species, but the specific molecular interaction mechanism has not been elucidated yet (denoted by “?” in the figure). The molecules in the boxes indicated by the arrows can interact with the prefoldin subunits. The alpha subunits (PFDN3 and PFDN5) of prefoldin play a tumor-suppressing role, and the beta subunits (PFDN1, PFDN2, PFDN4, and PFDN6) play a role in tumorigenesis. VHL: Von Hippel-Lindau; pVHL: von Hippel-Lindau protein; hMSH4: human MutS homologs 4; HDAC1: Histone deacetylase 1; DELLA: integrators of gibberellin (GA) action; TIF1β: transcriptional intermediary factor–1β; Rabring7: Rab7‐interacting ring finger protein; Egr-1: early growth response 1; ARFP/F: ARFP (alternative reading frame protein)/F (for frameshift); p73α and p63α: a member of the p53 family; ΔNp63α: the dominant negative isoform of the p63 family; cyclin A: cell cycle protein A; RABV: Rabies virus; FOXO: forkhead box class O; Rpb5: RNA polymerase II (RNAPII) subunit 5; TOR: target of rapamycin; PFDN6: prefoldin subunit 6; NF-κB; nuclear factor-kappaB; and Als2: amyotrophic lateral sclerosis type 2