Fig. 5

miR-320d/FoxM1 effect on the GCA tumor-bearing mice. Nude mice were subcutaneously injected with GCA cells. a Tumor volume of the mice implanted with EV-transfected or 320d mimics-transfected OE-19 cells during 4-weeks measurement. b Tumor volume of the mice implanted with EV-transfected or 320d-inhibitor transfected SK-GT2 cells. At the 4-weeks post-implantation, the mice were sacrificed and tumors were collected. c Tumor size in EV-transfected group or miR-320d mimics-transfected group. d Tumor size in EV-transfected group or 320d-inhibitor transfected group. e RT-qPCR analysis of FoxM1 mRNA in EV-transfected tumors or miR-320d mimics-transfected tumors. f Western-blot detected the expression of FoxM1 protein in EV-transfected tumors or miR-320d mimics-transfected tumors. The * represents significant difference from miR-320d vector-transfected tumors to EV-transfected tumors (*: P < 0.05; **: P < 0.01; ***: P < 0.001). Data are shown as mean ± SD