From: New insights into the cellular activities of Fndc5/Irisin and its signaling pathways
Source of irisin/Fndc5 | Target cells/tissue | Signaling pathway | Effects | References |
---|---|---|---|---|
Mouse embryoid bodies | Mouse Embryoid Bodies | ERK1/2 MAPK pathway | Facilitates neural differentiation | [8] |
Recombinant irisin | White Adipocytes | p38 and ERK MAP Kinase | Browning of white adipocytes | [21] |
Conditioned medium of 3T3-L1 cell line and myoblast | Primary rat osteoblast and MC3T3-E1 cell line and bone marrow stromal cells | p38 and ERK MAP Kinase | Osteoblast proliferation and differentiation | |
Recombinant irisin | Human endothelial cell | ERK1/2 MAPK | Endothelial cell proliferation | [34] |
Recombinant irisin | Primary-cultured myoblasts and L6 cells | P38 MAPK | Glucose uptake | [35] |
circulating irisin | Skeletal muscle | p38 MAPK and ERK MAPK | Insulin sensitivity | [40] |
Recombinant irisin | H19-7 hippocampal cell lines | STAT3 | H19-7 cell proliferation | [47] |
Fndc5 overexpression circulating irisin | Adipose tissue | AMPK pathway | Attenuates inflammation | [52] |
Recombinant irisin | A549 and NCI-H446 lung cancer cells | PI3K/AKT pathway | Anti-metastatic effects | [56] |
Recombinant irisin | U2OS cells (osteosarcoma cells) | STAT3/Snail signaling pathway | Anti-metastatic effects | [62] |
Skeletal muscle | White adipose tissue | AMPK-PGC1α-FNDC5 signaling pathway | Browning of WAT | [65] |
Recombinant irisin | RAW-264.7 cell line | TLR4/MyD88 Signaling Pathway | Anti-Inflammatory | [66] |
Recombinant irisin | Endothelial cells | AMPK-Akt-eNOS-NO Pathway | Lowers Blood Pressure | [68] |
Recombinant irisin | Cardiomyocyte and mouse heart | AMPK-ULK1 and AMPK- mTOR | Improves cardiac hypertrophy | |
Recombinant irisin | Human cortical slices Mouse hippocampal slices | cAMP/PKA/CREB | Roles in memory formation | [46] |
Recombinant irisin | PaCa-2 and Panc03.27 cells | AMPK-mTOR | Suppress pancreatic cancer cell | [63] |
Recombinant irisin | 3T3-L1 | Wnt signaling | Inhibit adipogenesis | [42] |
Hippocampus of mice | Hippocampus of mice | FNDC5/BDNF/Akt | antidepressant-like effect | [81] |