BRCA1 and homologous recombination: implications from mouse embryonic development

Cell & Bioscience

Table 2 Summary of Brca1 mutant embryos with rescued survival or prolonged development after additional gene disruption

Brca1 mutant allele (homozygous)	Additional gene disruption	Embryonic development phenotypes	References
Rescue of embryonic development defects by compromising p53 signaling
Brca1^Δ5-6	p53^−/−	Prolong the survival of embryo from E7.5 to E9.5	[63]
Brca1^Δ5-6	p21^−/−	Prolong the survival of embryo from E7.5 to E9.5	[63]
Brca1^ex2	p53^−/−	Improve the morphology of embryos at E8.5 and E9.5	[48]
Brca1¹¹⁻	p53^−/−	Extend the survival for 2 days	[42]
Brca1^Δ223-763	p53^−/−	Partially viable	[64]
Brca1^Δ11	p53^+/− or p53^−/−	Fully viable	[45]
Brca1^Δ11	Chk2^+/−or Atm^+/−	Partially viable	[67]
Brca1^Δ11	Chk2^−/− or Atm^−/−	Fully viable	[67]
Rescue of embryonic lethality by 53bp1 KO
Brca1^Δ11	H2ax^−/− or Rnf8^−/− or Rnf168^−/−	Embryonic lethal, fail to rescue	[69, 80]
Brca1^Δ11	53bp1^−/−	Fully viable	[69]
Brca1^Δ11	53bp1^S25A/S25A	Fully viable	[83]
Brca1^ex2	53bp1^−/−	Fully viable	[71, 72]
Brca1^ex2	Rnf168^−/−	Fully viable	[80]
Brca1^ΔC	53bp1^−/−	Fully viable	[56]
Brca1^Δ5-13	53bp1^−/−	Partially viable	[82]

ISSN: 2045-3701