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Table 2 Summary of Brca1 mutant embryos with rescued survival or prolonged development after additional gene disruption

From: BRCA1 and homologous recombination: implications from mouse embryonic development

Brca1 mutant allele (homozygous) Additional gene disruption Embryonic development phenotypes References
Rescue of embryonic development defects by compromising p53 signaling
 Brca1Δ5-6 p53−/− Prolong the survival of embryo from E7.5 to E9.5 [63]
 Brca1Δ5-6 p21−/− Prolong the survival of embryo from E7.5 to E9.5 [63]
 Brca1ex2 p53−/− Improve the morphology of embryos at E8.5 and E9.5 [48]
 Brca111− p53−/− Extend the survival for 2 days [42]
 Brca1Δ223-763 p53−/− Partially viable [64]
 Brca1Δ11 p53+/− or p53−/− Fully viable [45]
 Brca1Δ11 Chk2+/−or Atm+/− Partially viable [67]
 Brca1Δ11 Chk2−/− or Atm−/− Fully viable [67]
Rescue of embryonic lethality by 53bp1 KO
 Brca1Δ11 H2ax−/− or Rnf8−/− or Rnf168−/− Embryonic lethal, fail to rescue [69, 80]
 Brca1Δ11 53bp1−/− Fully viable [69]
 Brca1Δ11 53bp1S25A/S25A Fully viable [83]
 Brca1ex2 53bp1−/− Fully viable [71, 72]
 Brca1ex2 Rnf168−/− Fully viable [80]
 Brca1ΔC 53bp1−/− Fully viable [56]
 Brca1Δ5-13 53bp1−/− Partially viable [82]