Fig. 3

Clustering dependency analysis of FA core complex and ID2 complex components in multiple cancer lines by CRISPR knockout. Coefficient of paired dependency scores is evaluated systematically within 22 FA complementation groups. Wihle high coefficient suggests functional equality, low coefficient implies functional divergence. a FANCL and FANCI dependencies across over 600 cancer lines are strongly correlated. b FANCT and FANCD1 dependencies are poorly correlated. c Z scores of paired correlation efficiency scores (either Pearson or Spearman) are plotted in a diagonal table with color highlight. A clustering of FA core and ID2 complex components suggests similar cellular consequence when either individual gene is inhibited