A novel miR-0308-3p revealed by miRNA-seq of HBV-positive hepatocellular carcinoma suppresses cell proliferation and promotes G1/S arrest by targeting double CDK6/Cyclin D1 genes

Table 2 Top 20 differentially expressed miRNAs in the liver cancer patients with HBV infection

Differentially expressed miRNAs
Up-regulated miRNAs			Down-regulated miRNAs
miRNA	Fold	p value	miRNA	Fold	p value
hsa-miR-4686	5.998	3.54E−06	hsa-miR-520d-3p	− 9.7702	2.35E−05
hsa-miR-190a-3p	4.3576	0.012801	hsa-miR-520d-5p	− 9.1468	4.81E−05
hsa-miR-4662b	4.1318	0.042001	hsa-miR-523-3p	− 7.9785	6.01E−05
hsa-miR-2681-3p	4.0401	0.004185	hsa-miR-526b-5p	− 8.0522	0.000103
hsa-miR-4536-3p	4.0009	0.038069	hsa-miR-520f-5p	− 8.3933	0.000106
hsa-miR-3653-3p	3.834	0.006222	hsa-miR-515-5p	− 9.3867	0.000118
hsa-miR-4500	3.5273	0.097272	hsa-miR-516a-5p	− 7.6473	0.000156
hsa-miR-6134	3.5273	0.141727	hsa-miR-524-5p	− 8.0333	0.000169
hsa-miR-4732-5p	3.5273	0.142656	hsa-miR-517a-3p	− 7.5898	0.000182
hsa-miR-6125	3.4195	0.26662	hsa-miR-517b-3p	− 7.5898	0.000183
hsa-miR-3182	3.2327	0.005509	hsa-miR-526a	− 8.0758	0.000227
hsa-miR-3163	3.2311	0.196223	hsa-miR-518d-5p	− 8.0758	0.000227
hsa-miR-522-5p	3.1985	0.202067	hsa-miR-520c-5p	− 8.0758	0.000227
hsa-miR-592	3.1103	0.002617	hsa-miR-518c-5p	− 7.1951	0.000313
hsa-miR-490-3p	3.0333	0.010412	hsa-miR-517-5p	− 7.3786	0.000327
hsa-miR-2115-5p	2.9822	0.066198	hsa-miR-518a-3p	− 7.3697	0.000344
hsa-miR-1973	2.9822	0.101527	hsa-miR-520a-3p	− 8.7703	0.000355
hsa-miR-1258	2.9112	0.044361	hsa-miR-1251a-5p	− 7.4661	0.000366
hsa-miR-517a-3p	2.8827	0.021475	hsa-miR-518b	− 7.681	0.000384
hsa-miR-7850-5p	2.8156	0.29838	hsa-miR-372-3p	− 9.7702	2.35E−05

ISSN: 2045-3701