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Table 2 The gradient changes of differentially expressed genes associated with lymph node metastasis or TNM stages with the Kruskal–Wallis test, and the survival analysis of patients with the differentially expressed genes

From: Transcriptome analysis reveals an important candidate gene involved in both nodal metastasis and prognosis in lung adenocarcinoma

Genes Lymph node metastasis (N0–N1–N2) TNM stages Log-rank test
(I–II–III–IV)
Gradient change p Gradient change p p
NNAT NA 0.019 NA 0.025
VSX2 Yes, downtrend 0.008 0.586 0.08025
SCARNA7 Yes, downtrend 0.011 Yes, downtrend 0.018 0.34227
AL161668.1 NA 0 NA 0.002
SNORA12 NA 0.013 NA 0.003
GSG1L2 Yes, upward 0 0.604 0.36278
CYP2B6 0.287 NA 0.032
ALB 0.197 NA 0.008
VN1R35P Yes, upward 0.003 0.157 0.08025
SNORA71A NA 0.04 0.842
AL451054.3 NA 0 NA 0.012
AC105999.2 Yes, upward 0.042 Yes, upward 0.012 0.13752
RN7SL3 Yes, upward 0.048 0.266 0.09487
LINC01819 Yes, downtrend 0.016 NA 0.021
RANBP20P Yes, downtrend 0.019 Yes, downtrend 0.016 0.07001
RNU5A-1 0.066 Yes, downtrend 0.015 0.75953
RN7SKP255 0.101 NA 0.005
AL513304.1 Yes, upward 0.019 0.073 0.37489
HIST1H4F 0.191 NA 0
RN7SKP203 NA 0.006 0.334
HIST1H4L 0.342 NA 0.048
RN7SL769P NA 0.01 0.116
RN7SL151P Yes, downtrend 0.006 Yes, downtrend 0.009 0.28316
GKN1 NA 0.039 0.272
FXNP2 NA 0.006 0.508
RNY3 NA 0.003 0.067
AC112495.1 Yes, downtrend 0.012 NA 0.002 0.88522
SYNPR Yes, downtrend 0.034 Yes, downtrend 0.002 0.14163
RN7SL480P Yes, downtrend 0.03 0.169 0.97413
RN7SL116P Yes, downtrend 0.019 0.057 0.71102
AC036111.1 NA 0.004 0.195  
RNA5-8SP2 NA 0 0.088  
RN7SL300P NA 0.026 0.079  
HIST1H2AH Yes, upward 0.014 NA 0.012 0.89036
PSG11 0.126 NA 0.002  
GLRA4 Yes, downtrend 0.003 0.322 0.08082
RN7SL359P NA 0 0.052
AL135929.2 NA 0.006 0.14
CYP11B1 NA 0.029 0.123
RN7SL342P NA 0.02 0.062
SPAG11B Yes, upward 0.028 0.064 0.54783
RN7SL732P NA 0.005 0.082
CYP1D1P NA 0 NA 0.002
RN7SL791P NA 0 NA 0.002
RN7SKP189 NA 0.002 0.696
RN7SKP71 Yes, downtrend 0.011 NA 0.025 0.24259
RN7SL217P NA 0.029 NA 0.041
RN7SL272P NA 0 NA 0.016
RHOXF2B NA 0 0.093
RN7SL464P NA 0.003 0.214
CRISP1 NA 0.007 0.074
FGF4 0.379 NA 0.019
CRP NA 0.026 0.066
PSG2 0.347 NA 0.03
RN7SL197P NA 0.017 0.644
RN7SL646P NA 0.003 0.111
RN7SL554P NA 0.001 0.317
PPP1R3A NA 0.009 0.226
RN7SL597P 0.056 NA 0.017
RN7SL308P NA 0.001 NA 0.003
AC106872.1 NA 0 NA 0.003
AL135929.1 NA 0.007 0.086
AL512638.1 Yes, upward 0.002 Yes, upward 0 0.80925
RN7SL711P 0.104 Yes, downtrend 0.022 0.6968
HMGB3P18 NA 0.018 NA 0.022
RN7SL126P NA 0.021 0.106
RN7SL630P NA 0.002 0.066
RN7SL494P Yes, downtrend 0.025 0.057 0.02587
RN7SL7P NA 0.024 0.23
RN7SL786P NA 0.021 0.118
AC108515.1 NA 0 NA 0.005
RN7SKP185 NA 0.023 Yes, downtrend 0.02 0.66366
RN7SKP90 NA 0 Yes, downtrend 0.017 0.91288
AC008808.2 0.814 NA 0.024
RN7SL390P NA 0.012 0.445
SCARNA3 NA 0 NA 0.007
MIR124-2HG NA 0.002 NA 0.012
RN7SL297P NA 0.001 NA 0.002
RNU1-88P NA 0.004 0.35
RN7SL314P NA 0.078 NA 0.038
RN7SL575P NA 0.049 0.272
RN7SL302P NA 0.04 0.099
AL513475.2 NA 0.046 0.401
KRT38 0.148 Yes, upward 0.031 0.30421
OR4A16 NA 0.004 NA 0.003
FRG2 NA 0.003 0.699
LINC02557 NA 0.001 0.462
LINC01221 NA 0.002 0.076
AC012065.1 Yes, upward 0 NA 0 0.25382
LINC01040 NA 0.014 NA 0.024
IGLV3-26 NA 0.003 NA 0.011
CRCT1 Yes, upward 0.019 NA 0.013 0.51194
GAGE12 J NA 0.017 NA 0.007
CELA3A Yes, downtrend 0.035 NA 0.003 0.60893
RN7SL260P NA 0.005 0.102
AC245291.3 0.105 NA 0.018
AC105031.2 Yes, upward 0.001 NA 0.013 0.88735
AC245128.1 NA 0.008 NA 0.043
AC008517.1 NA 0.002 0.357
DRAXINP1 0.111 NA 0
RN7SL14P NA 0.032 0.214
DDX11L16 NA 0.002 NA 0.02
ANHX NA 0.043 NA 0.007
FAM9A NA 0.018 NA 0
TMIGD1 Yes, upward 0.001 Yes, upward 0.027 0.42473
PSG7 0.251 Yes, upward 0.001 0.74669
AC105460.1 NA 0.01 NA 0.001
AC080128.1 0.215 NA 0.036
BX510359.3 0.064 NA 0.002
AL139002.1 NA 0.022 0.747
MIR3976HG 0.195 NA 0.002
SPAG11A NA 0.003 NA 0.008
  1. d the deleted base, Pcorrected multiple testing by the Bonferroni correction, NA not applicable