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Table 2 The gradient changes of differentially expressed genes associated with lymph node metastasis or TNM stages with the Kruskal–Wallis test, and the survival analysis of patients with the differentially expressed genes

From: Transcriptome analysis reveals an important candidate gene involved in both nodal metastasis and prognosis in lung adenocarcinoma

GenesLymph node metastasis (N0–N1–N2)TNM stagesLog-rank test
(I–II–III–IV)
Gradient changepGradient changepp
NNATNA0.019NA0.025
VSX2Yes, downtrend0.0080.5860.08025
SCARNA7Yes, downtrend0.011Yes, downtrend0.0180.34227
AL161668.1NA0NA0.002
SNORA12NA0.013NA0.003
GSG1L2Yes, upward00.6040.36278
CYP2B60.287NA0.032
ALB0.197NA0.008
VN1R35PYes, upward0.0030.1570.08025
SNORA71ANA0.040.842
AL451054.3NA0NA0.012
AC105999.2Yes, upward0.042Yes, upward0.0120.13752
RN7SL3Yes, upward0.0480.2660.09487
LINC01819Yes, downtrend0.016NA0.021
RANBP20PYes, downtrend0.019Yes, downtrend0.0160.07001
RNU5A-10.066Yes, downtrend0.0150.75953
RN7SKP2550.101NA0.005
AL513304.1Yes, upward0.0190.0730.37489
HIST1H4F0.191NA0
RN7SKP203NA0.0060.334
HIST1H4L0.342NA0.048
RN7SL769PNA0.010.116
RN7SL151PYes, downtrend0.006Yes, downtrend0.0090.28316
GKN1NA0.0390.272
FXNP2NA0.0060.508
RNY3NA0.0030.067
AC112495.1Yes, downtrend0.012NA0.0020.88522
SYNPRYes, downtrend0.034Yes, downtrend0.0020.14163
RN7SL480PYes, downtrend0.030.1690.97413
RN7SL116PYes, downtrend0.0190.0570.71102
AC036111.1NA0.0040.195 
RNA5-8SP2NA00.088 
RN7SL300PNA0.0260.079 
HIST1H2AHYes, upward0.014NA0.0120.89036
PSG110.126NA0.002 
GLRA4Yes, downtrend0.0030.3220.08082
RN7SL359PNA00.052
AL135929.2NA0.0060.14
CYP11B1NA0.0290.123
RN7SL342PNA0.020.062
SPAG11BYes, upward0.0280.0640.54783
RN7SL732PNA0.0050.082
CYP1D1PNA0NA0.002
RN7SL791PNA0NA0.002
RN7SKP189NA0.0020.696
RN7SKP71Yes, downtrend0.011NA0.0250.24259
RN7SL217PNA0.029NA0.041
RN7SL272PNA0NA0.016
RHOXF2BNA00.093
RN7SL464PNA0.0030.214
CRISP1NA0.0070.074
FGF40.379NA0.019
CRPNA0.0260.066
PSG20.347NA0.03
RN7SL197PNA0.0170.644
RN7SL646PNA0.0030.111
RN7SL554PNA0.0010.317
PPP1R3ANA0.0090.226
RN7SL597P0.056NA0.017
RN7SL308PNA0.001NA0.003
AC106872.1NA0NA0.003
AL135929.1NA0.0070.086
AL512638.1Yes, upward0.002Yes, upward00.80925
RN7SL711P0.104Yes, downtrend0.0220.6968
HMGB3P18NA0.018NA0.022
RN7SL126PNA0.0210.106
RN7SL630PNA0.0020.066
RN7SL494PYes, downtrend0.0250.0570.02587
RN7SL7PNA0.0240.23
RN7SL786PNA0.0210.118
AC108515.1NA0NA0.005
RN7SKP185NA0.023Yes, downtrend0.020.66366
RN7SKP90NA0Yes, downtrend0.0170.91288
AC008808.20.814NA0.024
RN7SL390PNA0.0120.445
SCARNA3NA0NA0.007
MIR124-2HGNA0.002NA0.012
RN7SL297PNA0.001NA0.002
RNU1-88PNA0.0040.35
RN7SL314PNA0.078NA0.038
RN7SL575PNA0.0490.272
RN7SL302PNA0.040.099
AL513475.2NA0.0460.401
KRT380.148Yes, upward0.0310.30421
OR4A16NA0.004NA0.003
FRG2NA0.0030.699
LINC02557NA0.0010.462
LINC01221NA0.0020.076
AC012065.1Yes, upward0NA00.25382
LINC01040NA0.014NA0.024
IGLV3-26NA0.003NA0.011
CRCT1Yes, upward0.019NA0.0130.51194
GAGE12 JNA0.017NA0.007
CELA3AYes, downtrend0.035NA0.0030.60893
RN7SL260PNA0.0050.102
AC245291.30.105NA0.018
AC105031.2Yes, upward0.001NA0.0130.88735
AC245128.1NA0.008NA0.043
AC008517.1NA0.0020.357
DRAXINP10.111NA0
RN7SL14PNA0.0320.214
DDX11L16NA0.002NA0.02
ANHXNA0.043NA0.007
FAM9ANA0.018NA0
TMIGD1Yes, upward0.001Yes, upward0.0270.42473
PSG70.251Yes, upward0.0010.74669
AC105460.1NA0.01NA0.001
AC080128.10.215NA0.036
BX510359.30.064NA0.002
AL139002.1NA0.0220.747
MIR3976HG0.195NA0.002
SPAG11ANA0.003NA0.008
  1. d the deleted base, Pcorrected multiple testing by the Bonferroni correction, NA not applicable