Fig. 4
From: Hsa_circ_0051079 functions as an oncogene by regulating miR-26a-5p/TGF-β1 in osteosarcoma
Circ_0051079 played an oncogenic role in osteosarcoma cells via miR-26a-5p. a, b Cell proliferation ofU2OS and SaoS2 cells. U2OS and SaoS2 cells were transfected with circ_0051079 shRNA or miR-26-5p mimics for 24 h and then MTT assay was used to evaluate the cell proliferation of U2OS and SaoS2 cells. c, d Cell proliferation of U2OS and SaoS2 cells. U2OS and SaoS2 cells were transfected with circ_0051079 shRNA or miR-26-5p mimics for 24 h and then cell colony formation assay was used to evaluate the cell proliferation of U2OS and SaoS2 cells. e, f The migratory ability of U2OS and SaoS2 cells. U2OS and SaoS2 cells were transfected with circ_0051079 shRNA or miR-26a-5p mimics for 24 h and cell migration was analyzed. g, h The invasion ability of U2OS and SaoS2 cells. U2OS and SaoS2 cells were transfected with circ_0051079 shRNA or miR-26a-5p mimics for 24 h and cell migration was analyzed. i, j The growth curve of U2OS and SaoS2 cells in vivo. U2OS and SaoS2 cells with circ_0051079 shRNA or miR-26a-5p mimics were injected to the nude mice and the tumor size was recorded and analyzed every 7 days. **p < 0.01