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Table 9 Distribution and comparison of combined 5′/3′ haplotypes of MBL2 in cases and controls

From: Impact of SNPs interplay across the locus of MBL2, between MBL and Dectin-1 gene, on women’s risk of developing recurrent vulvovaginal infections

Haplotypes (5′ → 3′) No. (%) of controls No. (%) of cases Haplotype comparison
Total RVVI cases Clinical categories of RVVI RVVI vs controls BV vs controls VVC vs controls MI vs controls
(n = 218) (n = 218) BV (n = 112) VVC (n = 56) MI (n = 50) OR (95% CI) p value OR (95% CI) p value OR (95% CI) p value OR (95% CI) p value
Common
 5′H-10/3′H-2 24 (11.00) 23 (10.55) 9 (8.03) 8 (14.2) 6 (12.00) 1   1   1   1  
 5′H-5/3′H-1 12 (5.50) 16 (7.33) 9 (8.03) 3 (5.35) 4 (8.00) 1.39 (0.54–3.56) 0.492 2.00 (0.63–6.34) 0.2395 0.75 (0.16–3.35) 0.706 1.33 (0.31–5.64) 0.695
 5′H-3/3′H-3 15 (6.88) 10 (4.58) 4 (3.57) 3 (5.35) 3 (6.00) 0.69 (0.26–1.86) 0.469 0.71 (0.18–2.72) 0.618 0.60 (0.13–2.62) 0.497 0.80 (0.17–3.68) 0.774
 5′H-1/3′H-1 14 (6.42) 10 (4.58) 10 (8.92) 0 (0.00) 0 (0.00) 0.74 (0.27–2.01) 0.561 1.90 (0.62–5.81) 0.257 NA NA
 5′H-9/3′H-1 15 (6.88) 8 (3.66) 4 (3.57) 2 (3.57) 2 (4.00) 0.55 (0.19–1.56) 0.265 0.71 (0.18–2.72) 0.618 0.40 (0.07–2.14) 0.284 0.53 (0.09–2.99) 0.475
 5′H-1/3′H-2 9 (4.12) 11 (5.04) 4 (3.57) 5 (8.92 2 (4.00) 1.27 (0.44–3.64) 0.649 1.18 (0.29–4.83) 0.812 1.66 (0.43–06.45) 0.459 0.88 (0.15–5.24) 0.896
 5′H-35/3′H-3 4 (1.83) 11 (5.04) 5 (4.46) 3 (5.35) 3 (6.00) 2.86 (0.79–10.31) 0.106 3.33 (0.72–15.26) 0.121 2.25 (0.41–12.28) 0.349 3.00 (0.52–17.15) 0.216
 5′H-60/3′H-1 3 (1.37) 11 (5.04) 7 (6.25) 3 (5.35) 1 (2.00) 3.82 (0.94–15.49) 0.060 6.22 (1.31–29.44) 0.021* 3.00 (0.50–17.95) 0.228 1.33 (0.11–15.20) 0.816
  1. Global p-value for case/control haplotype association was 0.01
  2. NA not applicable
  3. * p ≤ 0.05; HTTAYGPA (5′H-9), LTTAYGQB (5′H-10), HTTAXGPA (5′H-35), HTTAXGQB (5′H-60)