Impact of SNPs interplay across the locus of MBL2, between MBL and Dectin-1 gene, on women’s risk of developing recurrent vulvovaginal infections

Table 12 Multifactor dimensionality reduction (MDR) analysis for the identification of best gene–gene interaction models for RVVI cases and controls

Models	SNPs interaction	Training balance accuracy	Testing balance accuracy	Cross validation consistency	OR (95% CI)	χ² value	p-value
1	MBL2.rs7096206 (Y/X)	0.637	0.637	10/10	3.25 (1.84–5.74)	17.15	< 0.0001*
2	MBL2.rs36014597, MBL2.rs7096206 (Y/X)	0.657	0.623	9/10	5.33 (2.71–10.50)	26.05	< 0.0001*
3	MBL2.rs7096206 (Y/X), MBL2.rs10824792, CLEC7A.rs3901533	0.702	0.637	5/10	5.73 (3.15–10.45)	35.10	< 0.0001*

ISSN: 2045-3701