Impact of SNPs interplay across the locus of MBL2, between MBL and Dectin-1 gene, on women’s risk of developing recurrent vulvovaginal infections

Table 10 Distribution of sMBL levels in cases and controls, stratified on the basis of 5′ block haplotypes of MBL2

Haplotypes	Controls		RVVI		p-value (controls vs RVVI)^†	BV		p-value (controls vs BV)^†	VVC		p-value (controls vs VVC)^†	MI		p-value (controls vs MI)^†
Haplotypes	n	Mean ± SD	n	Mean ± SD	p-value (controls vs RVVI)^†	n	Mean ± SD	p-value (controls vs BV)^†	n	Mean ± SD	p-value (controls vs VVC)^†	n	Mean ± SD	p-value (controls vs MI)^†
5′H-1	52	929.13 ± 328.26^a	98	796.14 ± 497.42	0.05*	33	756.96 ± 518.41	0.095	20	495.04 ± 146.90	6.5 × 10⁻¹¹***	16	774.02 ± 512.29	0.268
5′H-2	57	1229.7 ± 457.22^ab	50	964.66 ± 694.09^c	0.024*	19	711.44 ± 421.49	4.1 × 10⁻⁵***	16	568.28 ± 288.36	2.1 × 10⁻⁸***	6	912.34 ± 720.02	0.132
5′H-3	39	1053.3 ± 521.53	65	666.02 ± 450.61^c	1.2 × 10⁻⁴***	27	571.21 ± 222.96	3.8 × 10⁻⁶***	17	419.29 ± 282.35	3.2 × 10⁻⁷***	7	701.91 ± 401.10	0.098
5′H-4	51	1001.6 ± 333.61^b	51	703.54 ± 505.09	0.001***	12	763.35 ± 554.86	0.177	14	372.70 ± 182.16	1.7 × 10⁻¹¹***	10	691.51 ± 367.44	0.01**
5′H-5	24	1075.7 ± 353.79	64	896.52 ± 548.16	0.077	19	883.99 ± 511.06	0.210	14	563.78 ± 384.49	1.8 × 10⁻⁴***	14	990.78 ± 618.07	0.643
5′H-6	17	1188.7 ± 461.46	26	631.93 ± 248.25	1.5 × 10⁻⁴***	11	715.82 ± 302.77	0.003**	6	487.56 ± 220.87	1.1 × 10⁻⁴***	3	663.52 ± 23.84	2.4 × 10⁻⁴***
p-value^††		0.004*		0.008*			0.333			0.272			0.697

* p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001
^†Independent t-test between patients and controls as well as within groups
^††One Way ANOVA with overall p-value followed by Post Hoc Tukey test that further indicates values with similar letter are significantly different
^ap = 0.002, ^b p = 0.048, ^c p = 0.029

ISSN: 2045-3701