Triggers | Pathway | Function | References |
---|---|---|---|
mtDNA defect | Cn-calcium path way | EMT-like reprograming | [143] |
Epigenetic modification | Unclear | ||
Mitochondria metabolism disorder | HIF-α | Metabolism model shift | [136] |
NRF2 | Cell colony capacity | ||
Mitochondria redox signaling | Cell proliferation | ||
mtDNA defect/mitochondria metabolism disorder | Activation of ocogenic kinase | Cancer hallmark | [121] |
HnRNP A2 accumulation | Â |