Fig. 1

ATRA (1 µM) inhibited osteoclast precursor cells proliferation in presence or absence of BMP2/7 (5 or 50 ng/ml). Results of cell proliferation assay in RAW264.7 cell cultures (a). Cytotoxicity assay in BMM cell cultures (b), and RAW264.7 cell cultures (c). Values are mean ± SD, from three independent experiments. Significant effect of ATRA and/or BMP2/7 treatment, ****p < 0.0001, n.s. no significant difference