Fig. 5
From: INAVA promotes aggressiveness of papillary thyroid cancer by upregulating MMP9 expression
INAVA modulates MMP9 via regulating FGF1. mRNA levels of FGF1 were examined in INAVA-overexpressing (a) or -knockdown cells (b). c, d Protein levels of FGF1 were assessed in indicated cells. e ELISA assays were performed to assess the effect of INAVA on FGF1 release in TPC1 and K1 cells. f Knockdown of FGF1 by siRNAs in INAVA-overexpressing cells reversed increased level of MMP9. g Invasiveness caused by INAVA was abrogated by silencing FGF1 expression in INAVA-overexpressing cells. For a, b, e, g, results derived from three independent experiments are expressed as mean ± SD. *P < 0.05