Skip to main content

Advertisement

Fig. 2 | Cell & Bioscience

Fig. 2

From: Transplantation of endothelial progenitor cells attenuated paraquat-induced acute lung injury via miR-141-3p-Notch-Nrf2 axis

Fig. 2

EPCs alleviated the lung injury induced by paraquat (PQ) in vivo. C57BL/6J mice were randomly divided into four groups (n = 10 per group). The control group, mice received PBS by through tail vein injection; the EPCs group, mice were injected with EPCs (approximately 5 × 106 in 50 μL PBS through tail vein injection); the 10 × 106 EPCs group, mice were injected with approximately 10 × 106 EPCs in 50 μL PBS through tail vein; the PQ group, mice were received the intraperitoneal injection of PQ 50 mg/kg; the PQ + 1.25 × 106 EPCs group, mice were received the injection of PQ, and then received EPCs injection after 6 h; the PQ + 2.5 × 106 EPCs group, mice were received the injection of PQ, and then received EPCs injection after 6 h; the PQ + 5 × 106 EPCs group, mice were received the injection of PQ, and then received EPCs injection after 6 h; the PQ + 10 × 106 EPCs group, mice were received the injection of PQ, and then received EPCs injection after 6 h. a The lung W/D ratio, b lung injury score and c the number of total leukocyte and the number of neutrophils in BALF of the mice were detected. **P < 0.01 vs. control; ##P < 0.01 vs. PQ

Back to article page