Table 1 Similarities and disparities among apoptosis, SD, SICD and necrosis
Death mode | Who dies? | Who kills? | Prog. | Nature | Normal or not | Inflam. | R & H | Scar | Scavenged | Cell line | Cell–cell communication | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
w Scav. | w Nor. | S vs N | |||||||||||
Apoptosis | Normal but useless cell | Animal body | Yes | Suicide | Physiological | No | No | No | Evident | No | Yes | Yes | Yes |
SD | Normal but useful cell | Worn-out | Yes | Suicide | Physiological | No | Yes | No | Evident | No | Yes | Yes | No |
SICD | |||||||||||||
SIaLCD | Useful but damaged cell | Exo/endo stress | Yes | Suicide | Pathological | No | Yes | No | Evident | Yes | Yes | Yes | Yes |
SInLCD | Yes | Maybe | |||||||||||
Necrosis | Normal and useful cell | Exo stress | No | Homicide | Pathological | Yes | Yes | Maybe | Not evident | Yes | No | No | No |