Fig. 9
![Fig. 9](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs13578-017-0193-z/MediaObjects/13578_2017_193_Fig9_HTML.gif)
The ceRNA model was proposed to summarize lncRNA-H19/miR-29a-3p/E2F1 pathway. LncRNA-H19 negatively regulated miR-29a-3p in ccRCC, through binding to miR-29a-3p directly. In addition, miR-29a-3p targeted E2F1 and negatively regulated E2F1 expression, indicating that lncRNA-H19 could influence the expression of E2F1 in ccRCC through miR-29a-3p