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Fig. 5 | Cell & Bioscience

Fig. 5

From: Ginkgetin aglycone ameliorates LPS-induced acute kidney injury by activating SIRT1 via inhibiting the NF-κB signaling pathway

Fig. 5

Suppression of SIRT1 reversed the effect of GA on LPS-induced inflammatory response and renal injury in vitro. a The protein level of SIRT1 in si-SIRT1, si-control, or EX-527 treated HK-2 cells in vitro was assessed by western blot. The mRNA expressions and concentrations of IL-6 (b) and TNF-α (c) in LPS, LPS + GA, LPS + GA + si-SIRT1, and LPS + GA +EX-527 groups were determined by qRT-PCR in vitro. d The levels of iNOS, p-IκBα and IκBα in LPS, LPS + GA, LPS + GA + si-SIRT1, and LPS + GA +EX-527 groups were detected by western blot in HK-2 cells. n = 3, *P < 0.05

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