Fig. 7From: The miR-290-295 cluster as multi-faceted players in mouse embryonic stem cellsmiR-290-295 cluster is causatively involved in MEF senescence. miR-290-295 cluster induces senescence through activation of INK4a/ARF locus, and the possible mechanism is to downregulate LRF with activation of p19ARF and p53, and p16INK4a up-regulation by EZH2 down-regulationBack to article page