Fig. 1
From: Large is required for normal astrocyte migration and retinal vasculature development
PB insertion disrupted Large expression. a Schematic representation of partial Large genomic sequence from exon 6 (E6) to exon 8 (E8) and the insertion site of PB transposon. The genomic sequences adjacent to PB repeat termini are labeled next to PB transposon. Reverse transcription PCR (RT-PCR) primers are also labeled as F and B. PBR, PB repeat right termini. PBL, PB repeat left termini. Trap, gene trap element. b RT-PCR showed disrupted Large expression in the retinas of 2-month old Large PB/PB mice. c Quantitative real-time RT-PCR confirmed complete disruption of normal Large transcription in the retinas of 2-month old Large PB/PB mice