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Fig. 3 | Cell & Bioscience

Fig. 3

From: Phosphorylation of LSD1 by PLK1 promotes its chromatin release during mitosis

Fig. 3

Both amino terminus and carboxyl terminus of LSD1 are important for its interaction with PLK1. a Schematic diagram of LSD1. LSD1 encodes a polypeptide of 852 AAs with a SWIRM domain, a TOWER domain in between an amino amine oxidase (AOD) domain (AOD-N) and a carboxyl AOD domain (AOD-C). NT amino terminus; CT carboxyl terminus. b Both NT and CT of LSD1 are important for its direct interaction with PLK1. Bacterially produced GST fusions of LSD1 and its deletion mutants were used to pull down bacterially produced HIS-PLK1. An arrow points to the target protein

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