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Fig. 4 | Cell & Bioscience

Fig. 4

From: Vincristine alleviates adriamycin-induced nephropathy through stabilizing actin cytoskeleton

Fig. 4

VCR alleviates ADR-induced disorganization of actin cytoskeleton. ad Fluorescence microscope images of podocytes stained with Alexa 488 conjugated Phalloidin. a Well-organized linear actin fibers in control podocyte. b ADR treatment reduces the cell size of podocyte and diminished cytoplasmic actin fibers (arrow). c VCR treatment alone doesn’t change actin cytoskeleton distribution. d ADR-induced cellular changes are rescued by VCR treatment. e Quantitative comparison of cell size among different groups. f Quantitative comparison of actin fiber number among different groups. Data are presented as Mean ± SD. *p < 0.05

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