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Fig. 1 | Cell & Bioscience

Fig. 1

From: Targeted genome engineering in Caenorhabditis elegans

Fig. 1

Schematic representation of the ZFN and TALEN pairs. a Illustration of a pair of ZFNs bound to specific DNA sequences. Zinc finger modules are shown as rounded rectangle boxes. Each zinc finger binds to a particular nucleotide triplet. b Illustration of a pair of TALENs. TALE modules are represented as ellipses and each recognizes a specific nucleotide. The DNA binding domains of ZFN and TALEN are fused to a cleavage domain of FokI nuclease, therefore guide the FokI nuclease to the desired genomic loci and cleave the flanked spacer sequences

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