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Fig. 1 | Cell & Bioscience

Fig. 1

From: Germline mutations of KIT in gastrointestinal stromal tumor (GIST) and mastocytosis

Fig. 1

Schematic diagram of the tyrosine phosphorylation sites in wild-type c-Kit and their interaction molecules. KIT is a transmembrane receptor tyrosine kinase with an extracellular ligand-binding domain consisting of five immunoglobulin-like regions, a transmembrane domain, a juxtamembrane domain and an intracellular kinase domain which is separated by a short kinase insert. Upon binding of its ligand stem cell factor, some tyrosine sites as indicated in the intracellular domain of KIT are phosphorylated, leading to the activation of downstream signaling pathways

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