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Fig. 2 | Cell & Bioscience

Fig. 2

From: Long noncoding RNAs in DNA methylation: new players stepping into the old game

Fig. 2

The regulatory mechanisms of DNA methylation by lncRNAs. a lncRNA/DNMT1 interaction prevents locus-specific DNA methylation locally in cis (for example, ecCEBP). b lncRNA/DNMT1 interaction modulates DNA-methylation at distant genomic loci in trans, which may also require DNMT1-associated transcription factors (TFs) (for example, Dali). c lncRNA interacts with all three DNMTs (DNMT1, DNMT3a and 3b) to mediate/maintain local DNA methylation at the target promoter (for example, Dum). d lncRNA interacts with DNMT1 indirectly through a protein intermediate (for example, lincRNA-p21)

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