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Fig. 8 | Cell & Bioscience

Fig. 8

From: Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway

Fig. 8

The protective effect of H2S on vascular endothelial cells in type II diabetes model. HG and palmitate induces an increase in ROS production in vascular endothelial cells. Increased ROS leads to extremes oxidative stress which impairs ATP production. This alteration results in excessive autophagy, which finally induces cell death. Exogenous H2S attenuates ROS production through the Nrf2-ROS-AMPK pathway. Through attenuating ROS production, H2S inhibits this pathway, which reduces excessive autophagy. This effect of H2S can maintain the homeostasis of vascular endothelial cells and increase cell survival

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