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Fig. 1 | Cell & Bioscience

Fig. 1

From: On the way of revealing coactivator complexes cross-talk during transcriptional activation

Fig. 1

A scheme describing coactivator complexes participation in different stages of transcription activation cycle (scheme is described in detail in the body of the manuscript). In the presented scheme, two groups of symbols show coactivator complexes involved in each step of transcriptional activation and specific chromatin modifications characterizing different states of the gene between these steps. Transcription activation cycle includes following steps: repressors removal a activators recruitment b nucleosome removal c general transcription factors (GTFs) recruitment d Pol II recruitment and preinitiation complex (PIC) formation e, RNA synthesis initiation and capping f and transition into productive elongation g Following coactivator complexes are participated in transcription activation process: Mediator, NURF nucleosome remodeling factor, SWI/SNF switch/sucrose non-fermentable complex, INO80 INOsitol auxotrophy 80 complex, CHD1 chromodomain-helicase-DNA-binding protein 1 complex, Mi-2 complex formed by dermatomyositis-specific autoantigen Mi-2, KisL/CHD8 complex formed by Kismet/chromodomain-helicase-DNA-binding protein 8. Following chromatin modifications mark different states of the gene between steps of transcription activation: H1P phosphorylated histone H1, H2BK120Ub ubiquitinylated at K120 histone H2B, H3K4me3 trimethylated at K4 histone H3, H3S10P phosphorylated at Ser10 histone H3, H3K14Ac acetylated at K14 histone H3, H3R17me2–dimethylated at Arg17 histone H3, H4R3me2 dimethylated at Arg3 histone H4, H3K9Ac acetylated at K9 histone H3 and H3K36me3 trimethylated at K36 histone H3. These chromatin modifications are introduced/removed by following chromatin modifiers: SAGA Spt-Ada-Gcn5 acetyltransferase complex, Set1/MLL [Su(var)3-9, enhancer-of-zeste, Trithorax]1/mixed-lineage leukemia complex, CARM1 coactivator associated arginine methyltransferase 1, PRMT1 protein arginine methyltransferase 1, CBP/p300 CREB binding protein, KDM5/Lid lysine-specific demethylase 5, Bre complex formed by BREfeldin A-sensitivity protein 1, Set2 [Su(var)3-9, enhancer-of-zeste, trithorax]2 protein

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