Deficiency of myotubularin-related protein 14 influences body weight, metabolism, and inflammation in an age-dependent manner

Table 1 Metabolic and inflammatory variables in MTMR14 WT and KO mice

Variables	WT			KO
Variables	4 weeks	18 weeks	34 weeks	4 weeks	18 weeks	34 weeks
Body weight (g)	16.2 ± 0.2	27.4 ± 0.3	36.1 ± 3.1	17.5 ± 2.3	32.2 ± 2.1*	51.9 ± 4.9**
Daily food intake (g/mouse)	2.37 ± 0.14	2.98 ± 0.19	3.57 ± 0.15	2.41 ± 0.41	2.88 ± 0.22	3.51 ± 0.16
Body weight change (% of initial weight)	−10.16 ± 1.6	−8.4 ± 0.2	−8.26 ± 0.7	−10.23 ± 1.1	−8.54 ± 1.0	−5.84 ± 0.8*
TG (mg/dL)	96.49 ± 18.54	106.35 ± 19.80	115.78 ± 14.22	108.25 ± 17.64*	112.45 ± 16.73*	124.26 ± 23.61*
TC (mg/dL)	88.78 ± 14.43	91.57 ± 16.72	95.59 ± 17.35	87.35 ± 12.62	94.68 ± 14.24	106.93 ± 18.16 *
Blood glucose (0 min) (mg/dL)	69 ± 4	53 ± 4	61 ± 8	77 ± 13	72 ± 6*	81 ± 5*
Blood glucose (15 min) (mg/dL)	229 ± 25	224 ± 22	172 ± 8	243 ± 24	220 ± 11	251 ± 13**
Blood glucose (30 min) (mg/dL)	202 ± 11	206 ± 17	155 ± 11	210 ± 19	221 ± 23	208 ± 22*
Blood glucose (60 min) (mg/dL)	176 ± 14	166 ± 18	116 ± 10	178 ± 20	186 ± 8	157 ± 12*
Blood glucose (120 min) (mg/dL)	141 ± 6	107 ± 4	91 ± 13	139 ± 13	130 ± 14	124 ± 11*
Fat mass/body weight (mg/g)	20.82 ± 0.91	30.42 ± 0.79	22.96 ± 1.29	21.46 ± 0.82	31.23 ± 0.84	27.48 ± 1.22**
TNF-α (pg/mL)	1168 ± 184	1331 ± 146	1705 ± 182	1207 ± 193	1428 ± 173	3407 ± 289***
IL-6 (pg/mL)	176 ± 30	215 ± 13	316 ± 13	180 ± 31	210 ± 42	556 ± 107**
Leptin (pg/mL)	6615 ± 409	7150 ± 522	8678 ± 425	5767 ± 401	9025 ± 735	20436 ± 422***
Adiponectin (ng/mL)	379 ± 48	384 ± 64	308 ± 47	350 ± 29	329 ± 34	141 ± 27***

Body weight, daily food intake, body weight change, TG, TC, blood glucose level, fat mass/body weight, plasma TNF-α, IL-6, leptin and adiponectin of age-matched WT and KO mice were evaluated. Data are mean ± SD of 7–8 mice per group. All WT and KO data were statistically analyzed in an age-matched manner
* p < 0.05, ** p < 0.01, *** p < 0.001 vs. the respective WT group

ISSN: 2045-3701