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Table 1 Metabolic and inflammatory variables in MTMR14 WT and KO mice

From: Deficiency of myotubularin-related protein 14 influences body weight, metabolism, and inflammation in an age-dependent manner

Variables WT KO
4 weeks 18 weeks 34 weeks 4 weeks 18 weeks 34 weeks
Body weight (g) 16.2 ± 0.2 27.4 ± 0.3 36.1 ± 3.1 17.5 ± 2.3 32.2 ± 2.1* 51.9 ± 4.9**
Daily food intake (g/mouse) 2.37 ± 0.14 2.98 ± 0.19 3.57 ± 0.15 2.41 ± 0.41 2.88 ± 0.22 3.51 ± 0.16
Body weight change (% of initial weight) −10.16 ± 1.6 −8.4 ± 0.2 −8.26 ± 0.7 −10.23 ± 1.1 −8.54 ± 1.0 −5.84 ± 0.8*
TG (mg/dL) 96.49 ± 18.54 106.35 ± 19.80 115.78 ± 14.22 108.25 ± 17.64* 112.45 ± 16.73* 124.26 ± 23.61*
TC (mg/dL) 88.78 ± 14.43 91.57 ± 16.72 95.59 ± 17.35 87.35 ± 12.62 94.68 ± 14.24 106.93 ± 18.16 *
Blood glucose (0 min) (mg/dL) 69 ± 4 53 ± 4 61 ± 8 77 ± 13 72 ± 6* 81 ± 5*
Blood glucose (15 min) (mg/dL) 229 ± 25 224 ± 22 172 ± 8 243 ± 24 220 ± 11 251 ± 13**
Blood glucose (30 min) (mg/dL) 202 ± 11 206 ± 17 155 ± 11 210 ± 19 221 ± 23 208 ± 22*
Blood glucose (60 min) (mg/dL) 176 ± 14 166 ± 18 116 ± 10 178 ± 20 186 ± 8 157 ± 12*
Blood glucose (120 min) (mg/dL) 141 ± 6 107 ± 4 91 ± 13 139 ± 13 130 ± 14 124 ± 11*
Fat mass/body weight (mg/g) 20.82 ± 0.91 30.42 ± 0.79 22.96 ± 1.29 21.46 ± 0.82 31.23 ± 0.84 27.48 ± 1.22**
TNF-α (pg/mL) 1168 ± 184 1331 ± 146 1705 ± 182 1207 ± 193 1428 ± 173 3407 ± 289***
IL-6 (pg/mL) 176 ± 30 215 ± 13 316 ± 13 180 ± 31 210 ± 42 556 ± 107**
Leptin (pg/mL) 6615 ± 409 7150 ± 522 8678 ± 425 5767 ± 401 9025 ± 735 20436 ± 422***
Adiponectin (ng/mL) 379 ± 48 384 ± 64 308 ± 47 350 ± 29 329 ± 34 141 ± 27***
  1. Body weight, daily food intake, body weight change, TG, TC, blood glucose level, fat mass/body weight, plasma TNF-α, IL-6, leptin and adiponectin of age-matched WT and KO mice were evaluated. Data are mean ± SD of 7–8 mice per group. All WT and KO data were statistically analyzed in an age-matched manner
  2. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. the respective WT group