Fig. 2

Inferred transcriptional regulatory gene network in CRC. A newly developed computational model was utilized to identify target genes of seven cancer-related TFs and to construct gene regulatory networks. The triangular nodes represent corresponding TFs. Circle nodes refer to the target genes of TFs. Arrow lines show regulatory relationships from TFs to their target genes. Purple or blue lines stand for TFs that act as tumor suppressor or oncogene, respectively. Red and green nodes refer to over- and under-expressed genes, respectively