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Fig. 2 | Cell & Bioscience

Fig. 2

From: Co-administration with DNA encoding papillomavirus capsid proteins enhances the antitumor effects generated by therapeutic HPV DNA vaccination

Fig. 2

Characterization of antigen-specific CD8+ T cell immune responses generated by antigen-specific DNA vaccine mixed with HPV-16 L1 or L2 DNA. C57BL/6 mice (five per group) were vaccinated intradermally via gene gun with 2 μg/mouse of CRT/E7 or OVA DNA with or without HPV-16 L1 or L2 DNA twice at 1-week intervals. Splenocytes from vaccinated mice were collected 1 week after last immunization and the E7 or OVA-specific T cell immune responses were characterized using intracellular cytokine staining followed by flow cytometry analysis. a Representative flow cytometry data depicting the number of E7 (upper panel) or OVA (lower panel)-specific CD8+ T cells. b Bar graph representing the number of E7 (upper panel) or OVA (lower panel)-specific CD8+ T cells/3x105 splenocytes (mean± SD). Data shown are representative of two experiments performed. * indicates p < 0.05

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