Skip to main content


Fig. 3 | Cell & Bioscience

Fig. 3

From: Biologically active, high levels of interleukin-22 inhibit hepatic gluconeogenesis but do not affect obesity and its metabolic consequences

Fig. 3

IL-22TG6 mice with high levels of circulating IL-22 (~600 pg/ml) develop the same degree of HFD-induced obesity, insulin resistance, and fatty liver as wild-type littermates. Mice were fed a CD or HFD for 8 weeks. a Body weights were measured. b Total adiposity. c Glucose tolerance test (GTT). d Insulin resistance test (ITT). e Serum ALT and hepatic TG levels were measured. f Representative H&E staining of liver tissues from 8-week HFD fed mice. Values represent the mean ± SEM (n = 6-14)

Back to article page